| Bioactivity | DHFR-IN-17 (compound j9) is an oral active SaDHFR inhibitor with the IC50 of 0.97 nM. DHFR-IN-17 shows antibacterial activity against S. aureus with the minimum inhibitory concentration of 0.031 μg/mL[1]. |
| In Vivo | DHFR-IN-17 (compound j9) (2、5、10mg/kg，连续灌胃 3 天)可减轻 MRSA 诱导的 C57 小鼠表皮感染的皮肤感染损伤[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C17H21IN4O2 |
| Molar Mass | 440.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Huang Z, et al. Design, Synthesis, and Biological Evaluation of 5-(5-Iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine (AF-353) Derivatives as Novel DHFR Inhibitors against Staphylococcus aureus. J Med Chem. Published online March 11, 2024. |