| Bioactivity | DHFR-IN-13 (Compd Hit8) is an active R. solani DHFR inhibitor with an IC50 value of 10.2 μM. DHFR-IN-13 has selectivity of inhibition against human DHFR with an IC50 value of 227.7 μM. DHFR-IN-13 also is a fungicide. DHFR-IN-13 has high antifungal activity against R. solani with EC50 value of 38.2 mg/L[1]. |
| Target | IC50: 10.2 μM (R. solani DHFR); 227.7 μM (human DHFR); EC50: 38.2 mg/L (R. solani) |
| Name | DHFR-IN-13 |
| Formula | C24H24ClFN2O3S |
| Molar Mass | 474.98 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Feng R, et al. Discovery of Novel Rhizoctonia solani DHFR Inhibitors as Fungicides Using Virtual Screening. J Agric Food Chem. 2023 Dec 13;71(49):19385-19395. |