| Bioactivity | DHFR-IN-12 (Compound 5c) is a DHFR inhibitor which has good antibacterial activity[1]. |
| Invitro | DHFR-IN-12 (Compound 5c, 521μM) 具有较好的抗菌活性[1]。 0 --> DHFR-IN-12 相关抗体: |
| In Vivo | DHFR-IN-12 (5% w/v; 3 days) 可显著降低大鼠角膜炎感染。与 MRSA 组相比，DHFR-IN-12 处理的感染组的角膜混浊面积%明显减少[1]。 Animal Model: |
| Name | DHFR-IN-12 |
| Formula | C28H25N5O3 |
| Molar Mass | 479.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mansour B, et al. New Pyrazole-Clubbed Pyrimidine or Pyrazoline Hybrids as Anti-Methicillin-Resistant Staphylococcus aureus Agents: Design, Synthesis, In Vitro and In Vivo Evaluation, and Molecular Modeling Simulation[J]. ACS Omega, 2023. |