| Bioactivity | DHFR-IN-1 (compound 12) is a potent and selective DHFR (dihydrofolate reductase)inhibitor, with an IC50 of 40.71 nM. DHFR-IN-1 exhibits promising antibacterial activity against gram-positive and gram-negative bacteria. DHFR-IN-1 exhibits moderate antifungal activities. DHFR-IN-1 exhibits a high synergistic effect with Levofloxacin (HY-B0330), where the FIC (fractional inhibitory concentration index) value is 0.249[1]. |
| Target | IC50: 40.71 ± 1.86 nM (DHFR) |
| Name | DHFR-IN-1 |
| CAS | 2757991-65-2 |
| Formula | C22H22N6O4S2 |
| Molar Mass | 498.58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Alzahrani AY, et al. Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm activities with molecular modelling study. Bioorg Chem. 2022 Feb;119:105571. |
DHFR-IN-1
CAS: 2757991-65-2 F: C22H22N6O4S2 W: 498.58
DHFR-IN-1 (compound 12) is a potent and selective DHFR (dihydrofolate reductase)inhibitor, with an IC50 of 40.71 nM. DHF
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