| Bioactivity | DFP00173 is a potent and selective aquaporin-3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with an IC50 of ∼0.1-0.4 μM. DFP00173 is selective for AQP3 over the homologous AQP isoforms AQP7 and AQP9[1]. | ||||||||||||
| Invitro | DFP00173 inhibits the glycerol permeability of human erythrocytes with an IC50 of ~0.2 µM[1]. | ||||||||||||
| Name | DFP00173 | ||||||||||||
| CAS | 672286-03-2 | ||||||||||||
| Formula | C11H7Cl2N3O3S | ||||||||||||
| Molar Mass | 332.16 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Sonntag Y, et al. Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors. J Biol Chem. 2019 May 3;294(18):7377-7387. |
DFP00173
CAS: 672286-03-2 F: C11H7Cl2N3O3S W: 332.16
DFP00173 is a potent and selective aquaporin-3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with an IC50 of
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