| Bioactivity | DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor. DETA NONOate shows a slow release normal amounts of NO and long-acting[1][2]. | |||||||||
| Invitro | DETA NONOate (100 μM;16 h) 通过降低 M. abscessus subspecies abscessus (Mab) 的糖肽脂 (GPL) 表达诱导脓肿分枝杆菌复合体 (MABC) R 形态的生长[3]。 | |||||||||
| In Vivo | DETA NONOate (15-150 μg/大鼠, 脑室注射, 一次) 在大鼠福尔马林模型中表现出伤害感受器效应[2]。DETA NONOate (1µM) 可减少缺血或缺血/再灌注诱导的心脏线粒体损伤，并防止凋亡细胞死亡[4]。 Animal Model: | |||||||||
| Name | DETA NONOate | |||||||||
| CAS | 146724-94-9 | |||||||||
| Formula | C4H13N5O2 | |||||||||
| Molar Mass | 163.18 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Soichiro Sonoda, et al. Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells. Sci Rep. 2018 Feb 21;8(1):3419. [2]. S Shibuta, et al. A new nitric oxide donor, NOC-18, exhibits a nociceptive effect in the rat formalin model. EJ Neurol Sci. 1996 Sep 15;141(1-2):1-5 [3]. Nandanwar N, et al. Growth medium and nitric oxide alter Mycobacterium abscessus morphotype and virulence. Microbiol Res. 2021 Dec;253:126887. [4]. Umbrasas D, et al. Nitric Oxide Donor NOC-18-Induced Changes of Mitochondrial Phosphoproteome in Rat Cardiac Ischemia Model. Medicina (Kaunas). 2019 Sep 24;55(10):631. |
DETA NONOate
CAS: 146724-94-9 F: C4H13N5O2 W: 163.18
DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor. DETA NONOate shows a slow release normal amounts of NO a
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