| Bioactivity | DEALA-Hyp-YIPD is an HIF-1α peptide that inhibits VHL/HIF-1α interaction with an IC50 of 0.91 μM and a Kd of 180 nM[1]. |
| Target | IC50: 0.91 μM (VHL/HIF-1α interaction)Kd: 180 nM (VHL/HIF-1α interaction) |
| Name | DEALA-Hyp-YIPD |
| Sequence | Asp-Glu-Ala-Leu-Ala-{Hyp}-Tyr-Ile-Pro-Asp |
| Shortening | DEALA-{Hyp}-YIPD |
| Formula | C50H74N10O19 |
| Molar Mass | 1119.18 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Buckley DL, et al. Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction. J Am Chem Soc. 2012 Mar 14;134(10):4465-8. |