| Bioactivity | DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis[1][2][3]. | ||||||||||||
| Invitro | DCP-LA (100 nM; 15 min) activates cytosolic PKCε by binding to the phosphatidylserine binding/associating sites Arg50 and Ile89, without translocation towards the cell surface in PL-12 cells[1]. DCP-LA (10, 100, 100 nM; 10 min; 35 ℃) activates CaMKII and inhibits PP-1 in rat hippocampal neurons[2].DCP-LA (100 nM; 20 min) increases expression of the receptors on the plasma membrane, responsible for potentiate AMPA receptor responses in rat hippocampal slices[2].DCP-LA (100 nM; 10 min) results facilitation of hippocampal synaptic transmission[2].DCP-LA (100 nM; 24 h) prevents the Sodium nitroprusside (SNP, HY-10219) effect and rescues neurons from SNP-induced degradation[3].DCP-LA (100 nM; 12 h) abolishes the caspase-3/9 activation induced by Sodium nitroprusside (SNP, HY-10219) (1 mM)[3]. Cell Viability Assay[3] Cell Line: | ||||||||||||
| Name | DCP-LA | ||||||||||||
| CAS | 28399-31-7 | ||||||||||||
| Formula | C20H36O2 | ||||||||||||
| Molar Mass | 308.50 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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