| Bioactivity | DCI-Br-3 is a rapid, highly sensitive, and selective probe to monitor thiols in the epileptic brain. (λex=537 nm, λem=675 nm).DCI-Br-3 can effectively cross the blood-brain barrier (BBB)[1]. Storage: protect from light. |
| Invitro | DCI-Br-3 (0-20 μM; 30 min; SH-SY5Y cells) increases intracellular fluorescence in a concentration-dependent manner and has a good response to thiols in SH-SY5Y cells[1]. |
| In Vivo | DCI-Br-3 (5 mg/kg; i.p.; BALB/c mice) effectively crosses the blood-brain barrier and help monitor the decrease of thiols in the brain[1]. Animal Model: |
| Name | DCI-Br-3 |
| Formula | C25H20BrN3O2 |
| Molar Mass | 474.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang Y, et, al. Synergistic Modulation by Halogens and Pyridine Crossing the Blood-Brain Barrier for InSitu Visualization of Thiol Flux in the Epileptic Brain. Anal Chem. 2022 Oct 18;94(41):14443-14452. |