| Bioactivity | DCE_254 is an EZH2 inhibitor (IC50=11 μM) that also exhibits significant antiproliferative activity against lymphoma cell lines. DCE_254 inhibits the development of hypermethylation-related cancers by inhibiting the SAM-mediated methyl transfer process (IC50=10.3 μM)[1]. |
| CAS | 673443-80-6 |
| Formula | C21H17N9OS |
| Molar Mass | 443.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wu Y, et al. Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays[J]. Bioorganic & Medicinal Chemistry Letters, 2016, 26(15): 3813-3817. |