PeptideDB

DC432

CAS: 2388988-70-1 F: C55H100N28O10 W: 1313.56

HCT116 is a peptidomimetic inhibitor of N-terminal methyltransferase 1/2 (NTMT1/2) with an IC50 of 54 nM. HCT116 can inh
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Bioactivity HCT116 is a peptidomimetic inhibitor of N-terminal methyltransferase 1/2 (NTMT1/2) with an IC50 of 54 nM. HCT116 can inhibit the N-terminal methylation level of NTMT1/2 substrates in HCT116 cells, and is used for the study of NTMT1/2 probes.
Target IC50: 54 nM (NTMT1/2).
Name DC432
CAS 2388988-70-1
Sequence {p-Hydroxybenzeneacetic acid}-Pro-Lys-Arg-Arg-Arg-Arg-Arg-Arg-NH2
Shortening {p-Hydroxybenzeneacetic acid}-PKRRRRRR-NH2
Formula C55H100N28O10
Molar Mass 1313.56
Transport Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Reference [1]. Mackie BD, et al. Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies. J Med Chem. 2020 Sep 10;63(17):9512-9522.