| Bioactivity | HCT116 is a peptidomimetic inhibitor of N-terminal methyltransferase 1/2 (NTMT1/2) with an IC50 of 54 nM. HCT116 can inhibit the N-terminal methylation level of NTMT1/2 substrates in HCT116 cells, and is used for the study of NTMT1/2 probes. |
| Target | IC50: 54 nM (NTMT1/2). |
| Name | DC432 |
| CAS | 2388988-70-1 |
| Sequence | {p-Hydroxybenzeneacetic acid}-Pro-Lys-Arg-Arg-Arg-Arg-Arg-Arg-NH2 |
| Shortening | {p-Hydroxybenzeneacetic acid}-PKRRRRRR-NH2 |
| Formula | C55H100N28O10 |
| Molar Mass | 1313.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mackie BD, et al. Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies. J Med Chem. 2020 Sep 10;63(17):9512-9522. |
DC432
CAS: 2388988-70-1 F: C55H100N28O10 W: 1313.56
HCT116 is a peptidomimetic inhibitor of N-terminal methyltransferase 1/2 (NTMT1/2) with an IC50 of 54 nM. HCT116 can inh
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