| Bioactivity | DC07090 is a novel and potent small molecule inhibitor targeting the human enterovirus EV71 3C protease, with an IC50 value of 21.72 μM and no significant toxicity, as indicated by a CC50 greater than 200 μM. DC07090 can inhibit EV71 replication, with an EC50 value of 22.09 μM and a Ki value of 23.29 μM. DC07090 also inhibits the replication of Coxsackievirus A16 (CVA16), showing an EC50 value of 27.76 μM[1]. | ||||||||||||
| CAS | 879070-72-1 | ||||||||||||
| Formula | C18H14N4O | ||||||||||||
| Molar Mass | 302.33 | ||||||||||||
| Appearance | 粉末 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Guang-Hui Ma, et al. Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening. Eur J Med Chem. 2016 Nov 29:124:981-991. |