| Bioactivity | DC07090 dihydrochloride is a low toxicity, potent, reversible and competitive non-peptidyl human enterovirus 71 3C protease inhibitor with an IC50 and a Ki value for 21.72 μM and 23.29 μM. DC07090 dihydrochloride could also inhibit coxsackievirus A16 (CVA16) replication with an EC50 value of 27.76 μM[1]. |
| Target | IC50: 21.72 μM (EV71 3C protease).Ki: 23.29 μM (EV71 3C protease). EC50: 27.76 μM (coxsackievirus A16) |
| Invitro | DC07090 dihydrochloride forms stable hydrogen-bonding interactions with the main chains of S128, G145, G164 and hydrophobic interactions with F25, L125, L127 and F170. DC07090 dihydrochloride (0.01~10 μM) shows micromolar potency against EV71 3Cpro. DC07090 dihydrochloride exhibits a highly inhibitory potency on EV71 replication with an EC50 value of 22.09 μM. DC07090 dihydrochloride inhibits CVA16 with an EC50 value of 27.76 μM[1]. |
| Name | DC07090 dihydrochloride |
| CAS | 1158264-37-9 |
| Formula | C18H16Cl2N4O |
| Molar Mass | 375.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ma GH, et al. Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening. Eur J Med Chem. 2016 Nov 29;124:981-991. |
DC07090 dihydrochloride
CAS: 1158264-37-9 F: C18H16Cl2N4O W: 375.25
DC07090 dihydrochloride is a low toxicity, potent, reversible and competitive non-peptidyl human enterovirus 71 3C prote
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.