| Bioactivity | DAT1 is a potent antimitotic agent with anticancer effects. In HeLa cells, DAT1 blocks the spindle function by disturbing spindle microtubule and chromosome organization[1]. |
| Invitro | DAT1 显示出具有 GI50 值的细胞毒性在不同恶性细胞系（来自宫颈、结肠和肺的人类肿瘤细胞以及小鼠纤维肉瘤细胞）中浓度范围从 0.05 到 1 μM，平均值为 0.35 μM。DAT1 阻断前中期和中期的有丝分裂[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> DAT1 相关抗体: |
| CAS | 107401-70-7 |
| Formula | C17H15N3O2S |
| Molar Mass | 325.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Suparna Sengupta, et al. 4-Amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole (DAT1): a cytotoxic agent towards cancer cells and a probe for tubulin-microtubule system. Br J Pharmacol. 2005 Aug;145(8):1076-83. [2]. Nisha E Thomas, et al. Reversible action of diaminothiazoles in cancer cells is implicated by the induction of a fast conformational change of tubulin and suppression of microtubule dynamics. Mol Cancer Ther. 2014 Jan;13(1):179-89. |