| Bioactivity | DALDA is a potent and highly selective μ-opioid receptor agonist with a Ki of 1.69 nM. DALDA shows antinociceptive and respiratory effects[1]. |
| Invitro | DALDA 在生理 pH 值下携带净正电荷 (3+)，因此是亲水的，比吗啡更极性[1]。 |
| In Vivo | DALDA (0-7 nmol/rat; i.t.; once) 在大鼠中表现出抗痛和呼吸作用[1]。DALDA (0.1 and 1.0 μg/side; ICV; once) 在大鼠中产生双相效应，初始抑制，中间显著抑制，接着是水平运动、饲养和刻板印象次数的激活[2]。 Animal Model: |
| Name | DALDA |
| CAS | 118476-85-0 |
| Shortening | Y-{D-Arg}-FK-NH2 |
| Formula | C30H45N9O5 |
| Molar Mass | 611.74 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shimoyama M, et al. Antinociceptive and respiratory effects of intrathecal H-Tyr-D-Arg-Phe-Lys-NH2 (DALDA) and [Dmt1] DALDA. Journal of Pharmacology and Experimental Therapeutics, 2001, 297(1): 364-371. [2]. Meyer ME, et al. DALDA (H-Tyr-D-Arg-Phe-Lys-NH2), a potent mu-opioid peptide agonist, affects various patterns of locomotor activities. Pharmacol Biochem Behav. 1995 May;51(1):149-51. |