| Bioactivity | DALDA acetate is a potent and highly selective μ-opioid receptor agonist with a Ki of 1.69 nM. DALDA acetate shows antinociceptive and respiratory effects[1]. |
| Invitro | DALDA 醋酸盐在生理 pH 值下带有净正电荷 (3+)，因此比吗啡具有亲水性和更强的极性[1]。 |
| In Vivo | DALDA 醋酸盐（0-7 nmol/大鼠；i.t.；一次）在大鼠中表现出镇痛作用和呼吸作用[1]。DALDA 醋酸盐（0.1 和 1.0 μg/侧；ICV；一次）导致双相效应，初始抑制，中间显着抑制，随后激活大鼠的水平运动、竖立和刻板时间[2]。 |
| Name | DALDA acetate |
| Sequence | Tyr-{D-Arg}-Phe-Lys-NH2 |
| Shortening | Y-{D-Arg}-FK-NH2 |
| Formula | C32H49N9O7 |
| Molar Mass | 671.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shimoyama M, et al. Antinociceptive and respiratory effects of intrathecal H-Tyr-D-Arg-Phe-Lys-NH2 (DALDA) and [Dmt1] DALDA. Journal of Pharmacology and Experimental Therapeutics, 2001, 297(1): 364-371. [2]. Meyer ME, et al. DALDA (H-Tyr-D-Arg-Phe-Lys-NH2), a potent mu-opioid peptide agonist, affects various patterns of locomotor activities. Pharmacol Biochem Behav. 1995 May;51(1):149-51. |