DALDA TFA_product_DataBase

Bioactivity	DALDA TFA is a potent and highly selective μ-opioid receptor agonist with a Ki of 1.69 nM. DALDA TFA shows antinociceptive and respiratory effects[1].
Invitro	DALDA carrys a net positive charge (3+) at physiological pH and is thus hydrophilic and more polar than morphine[1]. 0 --> DALDA TFA 相关抗体:
In Vivo	DALDA (0-7 nmol/rat; i.t.; once) shows antinociceptive and respiratory effects in rats[1].DALDA (0.1 and 1.0 μg/side; ICV; once) results in biphasic effects, with an initial suppression, an intermediate marked inhibition, followed by activation for horizontal movement, rearing and stereotypy times in rats[2].
Name	DALDA TFA
Sequence	Tyr-{d-Arg}-Phe-Lys-NH2
Shortening	Y-{d-Arg}-FK-NH2
Formula	C30H45N9O5.xC2HF3O2
Molar Mass	611.74 (free base)
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Shimoyama M, et al. Antinociceptive and respiratory effects of intrathecal H-Tyr-D-Arg-Phe-Lys-NH2 (DALDA) and [Dmt1] DALDA. Journal of Pharmacology and Experimental Therapeutics, 2001, 297(1): 364-371. [2]. Meyer ME, et al. DALDA (H-Tyr-D-Arg-Phe-Lys-NH2), a potent mu-opioid peptide agonist, affects various patterns of locomotor activities. Pharmacol Biochem Behav. 1995 May;51(1):149-51.

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