DA 3003-2_product_DataBase

Bioactivity	DA 3003-2 is a potent and selectively Cdc25 inhibitor. DA 3003-2 shows antiproliferative activity. DA 3003-2 induces cell cycle arrest at the G2/M phase and increases the expression of P-tyr15 Cdc2. DA 3003-2 has the potential for the research of prostate cancer[1].
Invitro	DA 3003-2 (0.3-30 µM; 48 h) 在 PC-3 细胞中显示出抗增殖活性，IC50 值为 5 µM[1]。DA 3003-2 (5, 10 µM; 24, 1 h) 诱导细胞周期停滞在 G2/M 期并增加 PC-3 细胞中 P-tyr15 Cdc2 的表达[ 1]。 Cell Cytotoxicity Assay[1] Cell Line:
Name	DA 3003-2
CAS	383907-47-9
Formula	C15H16ClN3O3
Molar Mass	321.76
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Reference	[1]. Nemoto K. G2/M accumulation in prostate cancer cell line PC-3 is induced by Cdc25 inhibitor 7-chloro-6-(2-morpholin-4-ylethylamino) quinoline-5, 8-dione (DA 3003-2). Exp Ther Med. 2010 Jul;1(4):647-650.

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