| Bioactivity | DA-143 is a selective DNA-PKcs inhibitor (IC50: 2.5 nM), and the IC50s for mTOR, PI3KΔ, and ATM are 280 nM, 106 nM and 6,594 nM respectively. DA-143 blocks phosphorylation of DNA-PKcs substrates. DA-143 sensitizes cancer cells to Doxorubicin (HY-15142)[1]. |
| Formula | C34H32N4O3S |
| Molar Mass | 576.71 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Waldrip ZJ, et al. Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441. Sci Rep. 2024 Aug 28;14(1):19999. |