| Bioactivity | D4R antagonist-1 is a potent and selective D4R antagonist with an IC50 of 6.87 µM. D4R antagonist-1 has the potential for the research of Parkinson’s disease[1]. |
| Invitro | D4R antagonist-1 (compound 8c) shows good activity with an Ki of 135 nM[1]. |
| Name | D4R antagonist-1 |
| Formula | C21H25F2NO2 |
| Molar Mass | 361.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tolentino KT,et al. Discovery and characterization of benzyloxy piperidine based dopamine 4 receptor antagonists. Bioorg Med Chem Lett. 2022; 61:128615. |