| Bioactivity | D4R antagonist-2 is a potent and selective D4R antagonist with an IC50 of 6.52 µM. D4R antagonist-2 displays very favorable in vitro PK parameters and has good brain penetration. D4R antagonist-2 has the potential for the research of Parkinson’s disease[1]. |
| Invitro | D4R antagonist-2 (compound 11a) shows good activity with an Ki of 299.4 nM[1]. |
| In Vivo | D4R antagonist-2 displays very favorable in vitro PK parameters and is brain pentrent (Kp=2.9)[1].b>Pharmacokinetic Parameters of D4R antagonist-2 in rats[1]. rat cassette (0.25 mpk) |
| Name | D4R antagonis-2 |
| Formula | C21H23ClF2N2O2 |
| Molar Mass | 408.87 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tolentino KT,et al. Discovery and characterization of benzyloxy piperidine based dopamine 4 receptor antagonists. Bioorg Med Chem Lett. 2022; 61:128615. |