| Bioactivity | D359-0396 is an orally active NLRP3 inflammasome inhibitor. D359-0396 inhibits pyroptosis and IL-1β release in macrophages. D359-0396 also inhibits the oligomerization of NLRP3, ASC and the cleavage of GSDMD. D359-0396 alleviates EAE, and also improves survival after septic shock in mice[1]. |
| Target | NLRP3 inflammasome. |
| Name | D359-0396 |
| CAS | 1031977-31-7 |
| Formula | C24H24N4O2 |
| Molar Mass | 400.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li Z, et al. Identification of D359-0396 as a novel inhibitor of the activation of NLRP3 inflammasome. Neurochem Int. 2023 Oct;169:105565. |
D359-0396
CAS: 1031977-31-7 F: C24H24N4O2 W: 400.47
D359-0396 is an orally active NLRP3 inflammasome inhibitor. D359-0396 inhibits pyroptosis and IL-1β release in macropha
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