| Bioactivity | D159687 is a selective PDE4D inhibitor[1]. | ||||||||||||
| Target | PDE4D | ||||||||||||
| Invitro | D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment[1].D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM[1]. Western Blot Analysis[1] Cell Line: | ||||||||||||
| In Vivo | D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques[2]. Animal Model: | ||||||||||||
| Name | D159687 | ||||||||||||
| CAS | 1155877-97-6 | ||||||||||||
| Formula | C21H19ClN2O2 | ||||||||||||
| Molar Mass | 366.84 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Zhang C, et al. Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System. Sci Rep. 2017 Jan 5;7:40115. |