| Bioactivity | D-3, a phosphorpeptide, is an efficient, simple, and specific iPSC-eliminating agent[1]. |
| Invitro | D-3 prevents residual iPSC-induced teratoma formation in a mouse tumorigenicity assay[1].D-3 induces obvious loss of viability in 201B7 cells, with half maximal inhibitory concentration value of 192.3 ± 57.4 μM[1].D-3 induces an increase in the amount of activated elF2a, p38, and p44/42 MAPK, whichare activated in response to cellular stress. D-3 also increases the number of Annexin-V and SYTOX-positive cells, indicating apoptotic and dead cells after D-3 treatment[1].D-3 has little influence on various non-iPSCs, including hepatocytes and neurons[1]. Cell Viability Assay[1] Cell Line: |
| Name | D-3 |
| CAS | 1967815-98-0 |
| Formula | C48H47N4O10P |
| Molar Mass | 870.88 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |