D,L-erythro-PDMP hydrochloride_product_DataBase

Bioactivity	D,L-erythro-PDMP hydrochloride is an erythro isomer of PDMP. D,L-erythro-PDMP hydrochloride causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase[1][2].
Invitro	D,L-erythro-PDMP hydrochloride (0, 12, 25, 50 μM; 0, 4, 7, 10 d)显示出对兔皮肤成纤维细胞生长的抑制作用[1]。D,L-erythro PDMP hydrochloride (50 μM; 3 d)对兔皮肤成纤维细胞的细胞形态具有细胞毒性[1]。D,L-erythro-PDMP hydrochloride（40 μM；24 h；MDCK 细胞）诱导葡萄糖基转移酶比活性显着增加：14.6 nmol/h 每毫克蛋白质[2]。D,L-erythro-PDMP hydrochloride (40 μM; 6 h)保护细胞免受暴露于环己酰亚胺的细胞中合酶的损失[2]。
Name	D,L-erythro-PDMP hydrochloride
CAS	80943-40-4
Formula	C23H39ClN2O3
Molar Mass	427.02
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Uemura K, et al. Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblasts. J Biochem. 1990 Oct;108(4):525-30. [2]. Abe A, et al. Induction of glucosylceramide synthase by synthase inhibitors and ceramide. Biochim Biophys Acta. 1996 Feb 16;1299(3):333-41.

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