| Bioactivity | Cystathionine-γ-lyase-IN-1 is a selective cystathionine γ-lyase (CSE) enzyme inhibitor with an IC50 of 6.3 μM[1]. | ||||||||||||
| Target | IC50: 6.3 μM (CSE) | ||||||||||||
| Invitro | Cystathionine-γ-lyase-IN-1 (compound 2a) completely abrogates L-cysteine-induced vasorelaxation at a concentration of 100 μM[1].Cystathionine-γ-lyase-IN-1 (100 μM; 30 minutes) significantly inhibits the increased H2S production stimulated by L-Cys in mouse aorta homogenates[1]. | ||||||||||||
| Name | Cystathionine-γ-lyase-IN-1 | ||||||||||||
| CAS | 2165706-30-7 | ||||||||||||
| Formula | C7H8N2O2S | ||||||||||||
| Molar Mass | 184.22 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Angela Corvino, et al. Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production. Sci Rep. 2016 Oct 6;6:34398. |
Cystathionine-γ-lyase-IN-1
CAS: 2165706-30-7 F: C7H8N2O2S W: 184.22
Cystathionine-γ-lyase-IN-1 is a selective cystathionine γ-lyase (CSE) enzyme inhibitor with an IC50 of 6.3 μM.
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