| Bioactivity | Cys-McMMAF is the released payload of AlMcMMAF, an anti-5T4 humanized A1 antibody conjugated to the microtubule disrupting MMAF (HY-15579) via a maleimidocaproyl linker. Cys-McMMAF has antitumor efficacy in two tumor mouse models (H1975 and MDA-MB-361-DYT2 models)[1]. |
| In Vivo | Cys-McMMAF (0.3 mg/kg, 3 mg/kg; 静脉注射; 单剂量) 在食蟹猴体内的稳定性一般，衰退时间短[1]。在裸鼠 (nu/nu) 中的药代动力学分析[1]Model/IV |
| Name | Cys-McMMAF |
| CAS | 1160590-05-5 |
| Formula | C52H83N7O13S |
| Molar Mass | 1046.32 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Leal M, et al. Preclinical Development of an anti-5T4 Antibody-Drug Conjugate: Pharmacokinetics in Mice, Rats, and NHP and Tumor/Tissue Distribution in Mice. Bioconjug Chem. 2015 Nov 18;26(11):2223-32. |
Cys-McMMAF
CAS: 1160590-05-5 F: C52H83N7O13S W: 1046.32
Cys-McMMAF is the released payload of AlMcMMAF, an anti-5T4 humanized A1 antibody conjugated to the microtubule disrupti
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.