| Bioactivity | CypD-IN-3 is a potent and subtype-selective cyclophilin D (CypD) inhibitor. CypD-IN-3 has CypD affinity with an IC50 value of 0.01 μM. CypD-IN-3 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes[1]. |
| Target | IC50: 0.01 μM (CypD); 1.1 μM (CypA); 0.21 μM (CypB); 0.31μM (CypE) |
| Invitro | CypD-IN-3 (B52) has selectivity for inhibiting CypD, CypA, CypB and CypE with IC50 values of 0.01 μM, 1.1 μM, 0.21 μM and 0.31 μM, respectively[1].CypD-IN-3 (10 μM) inhibits mitochondrial permeability transition pore opening in isolated mitochondria[1]. |
| Name | CypD-IN-3 |
| CAS | 2651994-75-9 |
| Formula | C53H61N7O11 |
| Molar Mass | 972.09 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Alexander A Peterson, et al. Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nat Chem Biol. 2022 Sep 26. |
CypD-IN-3
CAS: 2651994-75-9 F: C53H61N7O11 W: 972.09
CypD-IN-3 is a potent and subtype-selective cyclophilin D (CypD) inhibitor. CypD-IN-3 has CypD affinity with an IC50 val
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