| Bioactivity | Cyclovalone is a synthetic curcumin derivate, which inihibits cyclooxygenase and exhibits anti-inflammatory, antitumor and antioxidant activities[1]. Cyclovalone inhibits cell proliferation in normal and malignant prostatic cells. Cyclovalone ist orally active[2]. |
| Invitro | Cyclovalone (0.2-10 μg/ml) 通过干扰细胞周期转变来抑制雄激素反应性 LNCaP 细胞和雄激素非依赖性 PC-3 细胞的增殖[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Cyclovalone 相关抗体: Cell Proliferation Assay[2] Cell Line: |
| In Vivo | Cyclovalone (9.5-38 mg/kg，口服 14 天) 是一种前列腺特异性拮抗剂，对 BALB/c 小鼠没有明显毒性[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 579-23-7 |
| Formula | C22H22O5 |
| Molar Mass | 366.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Itokawa H, et al., Recent advances in the investigation of curcuminoids. Chin Med. 2008 Sep 17;3:11. [2]. Markaverich BM, et al., Type II [3H]estradiol binding site antagonists: inhibition of normal and malignant prostate cell growth and proliferation. Int J Oncol. 1998 May;12(5):1127-35. |