| Bioactivity | Cyclotriazadisulfonamide hydrochloride (CADA hydrochloride) is a specific CD4-targeted HIV entry inhibitor with activity against HIV-1 replication. Cyclotriazadisulfonamide hydrochloride can specifically downregulate the expression of CD4 receptors on the surface of human cells. Cyclotriazadisulfonamide hydrochloride effectively inhibits HIV transmission in dendritic cells and is active against multiple HIV-1 subtypes. Cyclotriazadisulfonamide hydrochloride has shown protective effects against HIV-1 (NL4.3) and SIV (mac251) in experiments simulating human T cells. Cyclotriazadisulfonamide hydrochloride can produce synergistic inhibition of HIV and SIV infection when used in combination with cellulose acetate (CAP). Cyclotriazadisulfonamide hydrochloride as a microbial gel formulation can maintain CD4 downregulation and antiviral activity, showing its potential as a candidate for a broad-spectrum anti-HIV microbial compound[1]. |
| CAS | 392287-03-5 |
| Formula | C31H40ClN3O4S2 |
| Molar Mass | 618.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. CADA, a potential anti-HIV microbicide that specifically targets the cellular CD4 receptor |
Cyclotriazadisulfonamide hydrochloride
CAS: 392287-03-5 F: C31H40ClN3O4S2 W: 618.25
Cyclotriazadisulfonamide hydrochloride (CADA hydrochloride) is a specific CD4-targeted HIV entry inhibitor with activity
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