| Bioactivity | Cyclotraxin B, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B non-competitively inhibits BDNF-induced TrkB activity with an IC50 of 0.30 nM. Cyclotraxin B can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects[1][2][3]. | ||||||
| Name | Cyclotraxin B | ||||||
| CAS | 1203586-72-4 | ||||||
| Shortening | CNPMGYTKEGC (Disulfide bridge:Cys1-Cys11) | ||||||
| Formula | C48H73N13O17S3 | ||||||
| Molar Mass | 1200.37 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Stored under nitrogen, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture) |
Cyclotraxin B
CAS: 1203586-72-4 F: C48H73N13O17S3 W: 1200.37
Cyclotraxin B, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. C
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