| Bioactivity | Cyclosporin is a cyclic decapeptide that could be isolated form the soil fungi Tolypocladium inflatum. Cyclosporin is an immunosuppressant thought to bind to cyclophilin in T-lymphocytes[1]. |
| Invitro | Cyclosporin (0-2500 nM; Ppia-/- 细胞) 以相似的程度抑制 Ppia+/+ 或 Ppia+/- 脾细胞增值，IC50 值为 25 nM，Ppia-/- 脾细胞的 IC50 值至少高出 10 倍[1]。环孢菌素 (0-750 nM; Ppia-/- 细胞) 抑制 Ppia-/- 细胞中的基因表达[1]。 |
| Name | Cyclosporin |
| CAS | 79217-60-0 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Colgan J, et, al. Cyclophilin A-deficient mice are resistant to immunosuppression by cyclosporine. J Immunol. 2005 May 15;174(10):6030-8. |