| Bioactivity | Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A[1][2]. Cyclosporin A is a potent immunosuppressant drug, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc)[3]. | ||||||
| Invitro | Cyclosporine D inhibits Ca2+/calmodulin dependent EF-2 phosphorylation in vitro[1]. | ||||||
| Name | Cyclosporin D | ||||||
| CAS | 63775-96-2 | ||||||
| Sequence | cyclo ({Aaa}-Val-{Sar}-Leu-Val-Leu-Ala-Ala-Leu-Leu-{d-Val}) | ||||||
| Shortening | cyclo ({Aaa}-V-{Sar}-LVLAALL-{d-Val}) | ||||||
| Formula | C63H113N11O12 | ||||||
| Molar Mass | 1216.64 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Cyclosporin D
CAS: 63775-96-2 F: C63H113N11O12 W: 1216.64
Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard fo
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