| Bioactivity | Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM[3]. Cyclosporin A also inhibits CD11a/CD18 adhesion[8]. |
| Invitro | Cyclosporin A is able to bind with the cyclophilin in T cells[1]. Cyclosporin A works by forming a Cyclophilin-Cyclosporin A complex to inhibit calcineurin[2]. Cyclosporin A inhibits calcineurin in stimulated cells with an IC50 value of 7 nM[3]. Cyclosporin A suppresses the nuclear translocation of NF-AT[4]. Cyclosporin A shows an effect on mitochondria via preventing the MTP from opening with an IC50 of 39 nM[5]. |
| Name | Cyclosporin A |
| CAS | 59865-13-3 |
| Formula | C62H111N11O12 |
| Molar Mass | 1202.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
Cyclosporin A
CAS: 59865-13-3 F: C62H111N11O12 W: 1202.61
Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.