| Bioactivity | Cyclosporin A-Derivative 1 is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin. |
| Invitro | Cyclosporin A-Derivative 1 is a non-immunosuppressive Cyclosporine A derivative. The cyclosporin is acylated on the butenyl-methyl-threonine side chain and then subjected to a ring-opening reaction (the ring opens between the sarcosine and the N-methyl-leucine residues). Cyclosporin A-Derivative 1 is a linear peptide intermediate[1]. |
| Name | Cyclosporin A-Derivative 1 |
| CAS | 1487360-85-9 |
| Sequence | Leu-Val-Leu-Ala-{d-Ala}-Leu-Leu-Val-{Aaa}-{Abu}-{Sar} |
| Shortening | LVLA-{d-Ala}-LLV-{Aaa}-{Abu}-{Sar} |
| Formula | C65H118BF4N11O14 |
| Molar Mass | 1364.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Cyclosporin A-Derivative 1
CAS: 1487360-85-9 F: C65H118BF4N11O14 W: 1364.50
Cyclosporin A-Derivative 1 is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent
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