| Bioactivity | Cyclopeptide-5 (EMD 270179) is an aVβ3 antagonist that can improve PAF-induced increased adhesion of sickle red blood cells, capillary post-obstruction, and enhance blood flow dynamics. Cyclopeptide-5 also has cytotoxic effects[1][2]. |
| Target | aVβ3 |
| CAS | 197172-76-2 |
| Formula | C28H40N8O7 |
| Molar Mass | 600.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. M Abo-Ghalia, et al. Synthesis and investigation of a new cyclo (Nalpha-dipicolinoyl) pentapeptide of a breast and CNS cytotoxic activity and an ionophoric specificity. Amino Acids. 2004 Jun;26(3):283-9. [2]. Eileen M Finnegan, et al. Small-molecule cyclic alpha V beta 3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion. Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H1038-45. |
Cyclopeptide-5
CAS: 197172-76-2 F: C28H40N8O7 W: 600.67
Cyclopeptide-5 (EMD 270179) is an aVβ3 antagonist that can improve PAF-induced increased adhesion of sickle red blood c
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