| Bioactivity | Cycloguanil-d4 (hydrochloride) is the deuterium labeled Cycloguanil hydrochloride. Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1]. |
| Invitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| Name | Cycloguanil-d4 (hydrochloride) |
| CAS | 1189427-23-3 |
| Formula | C11H11D4Cl2N5 |
| Molar Mass | 292.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Matthaei J, et al. OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. Clin Pharmacol Ther. 2019 Jan;105(1):190-200. |
Cycloguanil-d4 (hydrochloride)
CAS: 1189427-23-3 F: C11H11D4Cl2N5 W: 292.20
Cycloguanil-d4 (hydrochloride) is the deuterium labeled Cycloguanil hydrochloride. Cycloguanil hydrochloride, the active
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