Cyclo(L-leucyl-L-tryptophyl)_product_DataBase

Bioactivity	Cyclo(L-leucyl-L-tryptophyl) (Cyclo(-Leu-Trp)) is a cyclic dipeptide that inhibits a various of bacteria and fungi. Cyclo(L-leucyl-L-tryptophyl) is a melatonin receptor agonist and is also used as a bitter ligand[1][2][3].
CAS	15136-34-2
Formula	C17H21N3O2
Molar Mass	299.37
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Kumar SN, et al. Purification, structural elucidation and bioactivity of tryptophan containing diketopiperazines, from Comamonas testosteroni associated with a rhabditid entomopathogenic nematode against major human-pathogenic bacteria. Peptides. 2014 Mar;53:48-58. [2]. Zubare-Samuelov M, et al. Some sweet and bitter tastants stimulate inhibitory pathway of adenylyl cyclase via melatonin and alpha 2-adrenergic receptors in Xenopus laevis melanophores. Am J Physiol Cell Physiol. 2003 Nov;285(5):C1255-62. [3]. Shiba T, et al. Some aspects of the relationship between the structure of a bitter diketopiperazine and its receptor. Biopolymers. 1981 Sep;20(9):1985-7.

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