| Bioactivity | Cyclo(L-Phe-L-Val) is a potent inhibitor of enzymes isocitrate lyase (ICL) (IC50=27 μg/mL). cyclo(L-Phe-L-Val) inhibits the gene transcription of ICL in C. albicans under C2-carbon-utilizing conditions[1]. |
| Target | Isocitrate lyase (ICL) |
| Invitro | Cyclo(L-Phe-L-Val) (32 μg/mL; 2 d) 分别降低白色念珠菌 SC5314 (野生型)、MRC10 (Δicl) 和 MRC11 (Δicl + ICL) 中的 icl 产物水平[1]。 |
| Name | Cyclo(L-Phe-L-Val) |
| CAS | 35590-86-4 |
| Formula | C14H18N2O2 |
| Molar Mass | 246.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kim H, et al. Inhibitory Effects of Diketopiperazines from Marine-Derived Streptomyces puniceus on the Isocitrate Lyase of Candida albicans. Molecules. 2019 Jun 4;24(11):2111. |
Cyclo(L-Phe-L-Val)
CAS: 35590-86-4 F: C14H18N2O2 W: 246.30
Cyclo(L-Phe-L-Val) is a potent inhibitor of enzymes isocitrate lyase (ICL) (IC50=27 μg/mL). cyclo(L-Phe-L-Val) inhibits
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