Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA_product_DataBase

Bioactivity

Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC) TFA, a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA can be used in the research of tumors[1].

Invitro

Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA (0.5 mM; 24 h) 下调 mESC 的转录因子 Oct 4、Sox 2 和 Nanog [1]。 Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA (0.5 mM) 抑制整合素基因表达 mESC-col I (I 型胶原蛋白) 构建[1]。 Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA (0.5 mM) 处理的 mESC 形成团聚体并从表面脱离[1]。

Name

Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA

Formula

C26H35F3N8O9S

Molar Mass

692.66

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

PeptideDB

Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA

CAS: F: C26H35F3N8O9S W: 692.66