| Bioactivity | Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the treatment of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease[1][2][3]. | ||||||
| Invitro | Cyclic somatostatin (0-10 μM; 15 min) dose-dependently inhibits the contractile response to isoprenaline in rat ventricular cardiomyocytes with an IC50 value of 13 nM[1]. | ||||||
| Name | Cyclic somatostatin | ||||||
| CAS | 38916-34-6 | ||||||
| Shortening | HAGCKNFFWKTFTSC-OH (Disulfide bridge: Cys3-Cys14) | ||||||
| Formula | C76H104N18O19S2 | ||||||
| Molar Mass | 1637.88 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
Cyclic somatostatin
CAS: 38916-34-6 F: C76H104N18O19S2 W: 1637.88
Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the treatment of severe, acute hemor
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