| Bioactivity | Cyclic-di-GMP is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP can be used in cancer research[1][2][3][4]. | ||||||||||||
| Invitro | Cyclic-di-GMP (0.5-50 µM; 5 days) inhibits proliferation of human colon cancer cells[1].Cyclic-di-GMP (0.5-50 µM; 5 days) specifically elevates CD4 expression in Jurkat cells[2].Cyclic-di-GMP (0.5-50 µM; 5 days) induces cell cycle arrest at the S-phase in Jurkat cells[2]. Cell Proliferation Assay[1] Cell Line: | ||||||||||||
| Name | Cyclic-di-GMP | ||||||||||||
| CAS | 61093-23-0 | ||||||||||||
| Formula | C20H24N10O14P2 | ||||||||||||
| Molar Mass | 690.41 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Cyclic-di-GMP
CAS: 61093-23-0 F: C20H24N10O14P2 W: 690.41
Cyclic-di-GMP is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth
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