| Bioactivity | Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels[1][2][3]. |
| Invitro | cADPR (20 nM) elicits a large rapid Ca2+ release in sea urchin eggs homogenates[1].cADPR (100 µM; 10 min) induces a sustained elevation of intracellular calcium concentration in a subset (64%) of cultured astrocytes[4].cADPR (100 µM) and heat (35-38.5 ℃) stimulates oxytocin OT release from the isolated hypothalami of male mice in culture[5]. |
| Name | Cyclic ADP-ribose |
| CAS | 119340-53-3 |
| Formula | C15H21N5O13P2 |
| Molar Mass | 541.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -80°C |
Cyclic ADP-ribose
CAS: 119340-53-3 F: C15H21N5O13P2 W: 541.30
Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-
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