| Bioactivity | Cyano-myracrylamide is an inhibitor of zinc finger DHHC domain-containing palmitoyltransferase 20 (zDHHC20) with an IC50 value of 1.35 µM. Cyano-myracrylamide also inhibits the S-Acylation of EGFR and CD36. Cyano-myracrylamide also inhibits S-acylation of Legionella E3 ligase GobX, MyD88, and Ras, which are substrates of zDHHC20, zDHHC9, and zDHHC6, respectively, in HEK293T cells expressing recombinant Legionella GobX, recombinant human MyD88, or endogenous Ras[1]. |
| CAS | 2801702-34-9 |
| Formula | C19H34N2O |
| Molar Mass | 306.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Azizi SA, et al. Development of an Acrylamide-Based Inhibitor of Protein S-Acylation. ACS Chem Biol. 2021 Aug 20;16(8):1546-1556. |
Cyano-myracrylamide
CAS: 2801702-34-9 F: C19H34N2O W: 306.49
Cyano-myracrylamide is an inhibitor of zinc finger DHHC domain-containing palmitoyltransferase 20 (zDHHC20) with an IC50
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