Bioactivity | CyPep-1 is a novel cationic lytic peptide with antitumor activity. CyPep-1 is highly cytotoxic by interacting with the negatively charged cell membrane of cancer cells. CyPep-1 has strong cytolytic activity on cancer cells both in vivo and in vitro, and can be used in the study of solid tumors[1]. |
Invitro | CyPep-1 (0-40 μg/mL;15-360 分钟) 以剂量和时间依赖的方式对肿瘤细胞系产生毒性,对正常细胞系影响较小[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CyPep-1 相关抗体: |
In Vivo | CyPep-1 (瘤内注射;1200 µg;单剂量) 在乳腺癌小鼠模型中具有抗肿瘤的作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
CAS | 1319804-91-5 |
Sequence | Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Lys-Thr-Leu-Arg-Val-Ala-Lys-Ala-Ile-Tyr-Lys-Arg-Tyr-Ile-Glu |
Shortening | YGRKKRRQRRRGKTLRVAKAIYKRYIE |
Formula | C152H265N57O35 |
Molar Mass | 3451.09 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Szczepanski C, et al. Identification of a novel lytic peptide for the treatment of solid tumours. Genes Cancer. 2014 May;5(5-6):186-200. |