| Bioactivity | Crobenetine (BIII-890), a benzomorphan derivative, is a potent, selective, and highly use-dependent Na+ channel blocker. Crobenetine displaces [3H]BTX from site 2 of the Na+ channel (IC50=49 nM) in rat brain synaptosomes, yet exhibits only low binding affinity for other receptors and ion channels. Crobenetine protects brain tissue from the deleterious effects of focal cerebral ischemia in rodents[1]. |
| In Vivo | Crobenetine (BIII-890；BIII 890 CL；3-30 mg/kg；皮下注射) 在永久性局灶性脑缺血后 5 分钟给药，可减少小鼠和大鼠的病变大小, 且不损害运动协调性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 221019-25-6 |
| Formula | C25H33NO2 |
| Molar Mass | 379.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. A J Carter, et al. Potent blockade of sodium channels and protection of brain tissue from ischemia by BIII 890 CL. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4944-9. |