Crisnatol mesylate_product_DataBase

Bioactivity	Crisnatol (BWA770U) mesylate is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol mesylate shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts[1][2][3].
Invitro	Crisnatol (1.3 μg/mL; 24-72 h) mesylate 抑制 HepG2 细胞的复制，使细胞活力降低 35%[2]。 Cell Viability Assay[2] Cell Line:
In Vivo	Crisnatol (25 mg/kg; p.o.; single dose) mesylate 显示出口服活性，并通过放射自显影显示大鼠粪便提取物的稳定代谢物谱[2]。
Name	Crisnatol mesylate
CAS	96389-69-4
Formula	C24H27NO5S
Molar Mass	441.54
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Adams DJ. In vitro pharmacodynamic assay for cancer drug development: application to crisnatol, a new DNA intercalator. Cancer Res. 1989 Dec 1;49(23):6615-20. [2]. Patel DK, et al. Metabolism of a novel antitumor agent, crisnatol, by a human hepatoma cell line, Hep G2, and hepatic microsomes. Characterization of metabolites. Biochem Pharmacol. 1991 Jul 5;42(2):337-46. [3]. Patel DK, et al. Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat. Drug Metab Dispos. 1991 Mar-Apr;19(2):491-7.

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