Cotransin_product_DataBase

Bioactivity	Cotransin is a Sec61 translocation inhibitor that acts in a signal-sequence-discriminatory manner to prevent the stable insertion of select nascent chains into the Sec61 translocation channel. Cotransin selectively inhibits the expression of VCAM-1 and p-selectin proteins by inhibiting their co-translational translocation across endoplasmic reticulum (ER) membranes (IC50=0.5-5 µM). Cotransin has potential for studying inflammation and immunity[1][2].
Invitro	Cotransin 通过抑制这些蛋白质跨内质网 (ER) 膜的共翻译易位来抑制 VCAM-1、P-选择素、血管紧张素原、β-内酰胺酶、CRF1、ETBR、AQP2、HER-3 和 TNF-α 的表达，其 IC50 范围为 0.5-5 µM[1]。Cotransin 抑制分泌蛋白和膜蛋白的子集的表达[2]。Cotransin (1, 5 µM; 24 h) 在 COS-7 细胞中，对 VCAM1 显示出选择性、有效和可逆的抑制作用[2]。Cotransin 阻止 Sec61 复合物的信号序列识别[2]。 Western Blot Analysis[2] Cell Line:
Name	Cotransin
CAS	863753-73-5
Formula	C42H68N6O8
Molar Mass	785.02
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

PeptideDB