| Bioactivity | Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals[1]. |
| CAS | 485803-62-1 |
| Sequence | Pro-Cys-Phe-{d-Trp}-Lys-Thr-Cys-Lys-NH2 (disulfide bridge: Cys2-Cys7) |
| Shortening | PCF-{d-Trp}-WKTCK-NH2 (disulfide bridge: Cys2-Cys7) |
| Formula | C47H68N12O9S2 |
| Molar Mass | 1009.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. F Prodam, et al. Cortistatin-8, a synthetic cortistatin-derived ghrelin receptor ligand, does not modify the endocrine responses to acylated ghrelin or hexarelin in humans. Neuropeptides. 2008 Feb;42(1):89-93. |
Cortistatin-8
CAS: 485803-62-1 F: C47H68N12O9S2 W: 1009.25
Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gas
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.