| Bioactivity | Corifollitropin alfa (Org 36286) is a long-acting recombinant follicle-stimulating hormone (FSH) analog. Corifollitropin alfa is a FSH Receptor agonist with an EC50 of 5.0 pM. Corifollitropin alfa stimulates ovulation and can be used in the research of infertility[1][2][3]. |
| Target | FSH Receptor |
| In Vivo | Corifollitropin alfa (20 μg/kg, s.c., single injection) shows a t1/2 of 17.3 h and Cmax of 3.2 ng/mL/μg/kg in female Wistar rats[2].Corifollitropin alfa (2.5-40 μg/kg, s.c.) stimulates superovulation in rats[2].Corifollitropin alfa (3 µg, supplemented with hCG, s.c.) increases ovulation rate and recovered embryos in rabbits[3]. Animal Model: |
| Name | Corifollitropin alfa |
| CAS | 195962-23-3 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Loutradis D, et al. Corifollitropin alfa, a long-acting follicle-stimulating hormone agonist for the treatment of infertility. Curr Opin Investig Drugs. 2009 Apr;10(4):372-80. [2]. Verbost P, et al. Pharmacologic profiling of corifollitropin alfa, the first developed sustained follicle stimulant. Eur J Pharmacol. 2011 Jan 25;651(1-3):227-33. [3]. Viudes-de-Castro MP, et a. A single injection of corifollitropin alfa supplemented with human chorionic gonadotropin increases follicular recruitment and transferable embryos in the rabbit. Reprod Domest Anim. 2019 Apr;54(4):696-701. |